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3 years agoWhy measles vaccine is given at 4th visit?. What about if we give the measles vaccine the child on admission if he is 9 months or older? Delaying a child a 9 months or older child to get vaccine, due to the protocol says at 4th visit?
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2 years agomeasles injection is given on the 4th visit for severely malnourished children because of the reductive adaptation process that makes the body not to make antibodies once the injection is given to the child. The antibodies starts to form by the 4h week thats when the immune system is able to mount an attack. Below 4weeks these systems(endocrine, immune) are not able to function so giving Measles vaccines will not trigger any antibody formation that will mount protection against measles
Remember measles vaccine is live attenuated
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2 years agoHi Masud,
There are numerous protocols and you should follow those in your national guidelines.
The rationale for giving a vaccine on the 4th visit was a compromise position between giving 2 doses, once on admission and once on discharge - the immune response supposedly improving during recovery from SAM, and adequately by the 4th week. This assumption of adequate recovery by week 4 obviously has a number of limitations for individuals. Not all children recover the same and some children will default from treatment before week 4.
Emergency programmes also advocated giving children aged 6-12 months the measles vaccine in OTP to be repeated on discharge or when the child reaches 9 months (the assumed age when the immune system reaches maturity). Alternatively, guidelines for programmes integrated into primary health services will suggest 'referral to EPI' (excluding children 6-8 month old). This is probably an acceptable approach where national / local measles coverage is high.
Which is the best approach is context dependent. Where there is low vaccination coverage or where a lot of default from OTP occurs early in treatment, one might consider giving the vaccination on admission - including children 6-8 months.
Jones and Berkely (2014) write "the suggestion that delayed vaccination is more likely to result in protective titres is not supported by available evidence". The article also provides WHO guidance on age-related vaccination in children with SAM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266374/
I hope this helps,
Paul
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